Hydroxychoroquine/Azithromycin/Zinc Sulfate

[Conager]

Do you guys actually type all those words?

Well, "type" is a bit anachronistic, isn't it?

The way I got started collecting obsolete technology was when I realized with lament that one never sees typewriters at second hand stores anymore. They are expensive collectors items. Especially some of those beautiful old Royalnd and Underwoods. (I recently acquired a bery nice, manual Hermes, myself.)

No one types, really. We still have "keys" though arranged "Qwerty" style courtesy of Scholes and Glidden.

Me, I mostly voice to text at rate of about 150+ garbled words a minute. I go back, excessively punctuate, (add parenthetical asides) and clean it up in classic hunt-and-butters-pecked fashion on a tiny 2" by 1.5' "keyboard." Often the clean up is like leaving the spigot running whilst I mop up the flood.

Talk about ironic non sequiters: I collect mid century irons, yet I rarely iron.

 

[Conager]

Let's see, who has the most posts in a thread about quack cures?
Yup, no surprise there.

oh, wow. Zing!

What did I win?

Talk about Rory-level meaningless post counts! Do you even read for content, or do you just sound out the words, Luk-style?

How many of my posts, in this thread are specifically about cures, or even medicine, much less "quack" cures? What do you consider a "quack" cure? All off-label use of approved medications in (now) common use by prescription of hundreds of individual physicians, or just this one?

Follow-up question: did you get your medical training from the same diploma mill that Rory got his degree in rocket surgery malpractice law?

You know, my post count would have been much higher had I responded to all the nitwits in the thread directly attacking my assertion that the DOD had "refudiated" the ABC story on the fabricated IC leak?

To wit:

When Que is triggered, and has backed himself into a corner demonstrating how ignorant he really is...yes...words galore appear, attempting to hide the mess he created

How did I "back myself into a corner" by correctly asserting that the DIA had issued the statement that clearly they did to the astonishment of you functional illiterates that cant read anything that cannot be emblazoned across a meme or doesn't fit in a tweet?

 

[sygn]

Hydrocholoquine needs one of those fancy names they dream up for drugs so we can start making ads.

Without an ad campaign and the right name... this pandemic will never end.

Socialitrex ?

Do you guys actually type all those words?

can you imagine that a drug has become so vital to both sides
only because Trump mentioned it?

 

[sigh]

It may end up not being efficacious, but there is nothing retarded about taking it under a physician's (not named Sean) care. It is still given en masse and to travelers prophylactically* in areas where malaria is common [/SIZE]

No it isn't. It's hardly used for malaria anywhere anymore because for the most part, the infecting parasite has become resistant to it. The most commonly used cocktail used for prophylaxis and treatment for malaria is a mix of Atovaquone-proguanil and doxycycline, plus mefloquine or tafenoquine. Tafenoquine is used in some areas because of developing resistance to mefloquine.

Hydroxychloroquine is barely mentioned for malaria anymore. Like chloroquine it's just not efficacious. And yes, it is dangerous. It can trigger arrhythmias even in patients without previous heart disease and its elimination half life is more than a month, meaning it takes a looooooooooooong time (at least 5 months) for it to clear the body. So if you do have a bad reaction to it, it ain't going away any time soon.

So what we have, then, is a a drug with an unknown (definitely unproven) potential for shortening recovery time from coronavirus, but with a well-proven, and fully accepted potential for serious harm, even death. Back when hydroxychloroquine was used for malaria, the risk was balanced by the known benefit it held for treating and preventing malaria. Totally different risk/benefit ratio. Apples and oranges comparison.

And no, despite the wisdom of Lance, maybe doesn't mean yes.

 

[Saint_Ann]

No it isn't. It's hardly used for malaria anywhere anymore because for the most part, the infecting parasite has become resistant to it. The most commonly used cocktail used for prophylaxis and treatment for malaria is a mix of Atovaquone-proguanil and doxycycline, plus mefloquine or tafenoquine. Tafenoquine is used in some areas because of developing resistance to mefloquine.

Hydroxychloroquine is barely mentioned for malaria anymore. Like chloroquine it's just not efficacious. And yes, it is dangerous. It can trigger arrhythmias even in patients without previous heart disease and its elimination half life is more than a month, meaning it takes a looooooooooooong time (at least 5 months) for it to clear the body. So if you do have a bad reaction to it, it ain't going away any time soon.

So what we have, then, is a a drug with an unknown (definitely unproven) potential for shortening recovery time from coronavirus, but with a well-proven, and fully accepted potential for serious harm, even death. Back when hydroxychloroquine was used for malaria, the risk was balanced by the known benefit it held for treating and preventing malaria. Totally different risk/benefit ratio. Apples and oranges comparison.

And no, despite the wisdom of Lance, maybe doesn't mean yes.

Allergic reaction to quinine is not rare.

 

[dolf]

I perused online a little. In the French study, it's been pointed out (by smart and qualified types) that patients who did badly (of which there were several) dropped out of the study and were omitted from the results. That's just bad science. If you don't include anyone who does badly your study will show a near total success rate, and it will be entirely meaningless.

Oh, and anyone who doesn't agree with me is a left/right wing nut, a poppyhead and a moron. Or something like that. Fucksake

 

[sigh]

Allergic reaction to quinine is not rare.

Only if you get it through tonic water, liberally laced with gin.

 

[thør]

I'm almost out of gin, but I have potato vodka.

 

[Saint_Ann]

Room temperature gin out of a dirty coffee mug sounds like a 40's private dick movie.

 

[sigh]

I perused online a little. In the French study, it's been pointed out (by smart and qualified types) that patients who did badly (of which there were several) dropped out of the study and were omitted from the results. That's just bad science. If you don't include anyone who does badly your study will show a near total success rate, and it will be entirely meaningless.

Oh, and anyone who doesn't agree with me is a left/right wing nut, a poppyhead and a moron. Or something like that. Fucksake

The French study is horrible. Badly constructed and poorly written. We may indeed eventually find out it does work but I'm not holding my breath. On the other hand, when a patient's condition declines and little hope and no other treatment is to be had, then the risk/benefit ratio shifts so that it might be judged to be worth a try. But we're talking about an end of life scenario.

But for prophylactic use at this stage? We don't have even anecdotal evidence to support that. All risk, no benefit. No way.

 

[sigh]

I'm almost out of gin, but I have potato vodka.

Vodka tonic is even better than gin. Squeeze of lime and lots of ice.

Summer is coming. What a great summer drink.

 

[dolf]

The French study is horrible. Badly constructed and poorly written. We may indeed eventually find out it does work but I'm not holding my breath. On the other hand, when a patient's condition declines and little hope and no other treatment is to be had, then the risk/benefit ratio shifts so that it might be judged to be worth a try. But we're talking about an end of life scenario.

But for prophylactic use at this stage? We don't have even anecdotal evidence to support that. All risk, no benefit. No way.

The thing a lot of people don't get is that being a doctor (incredibly smart and educated as they are) doesn't automatically mean they know diddly squat about running a trial. It's like assuming an architect will know how the electrics work. The average doc is probably as prone as any other person to confirmation bias, wishful thinking, and not considering every contributing factor.

And, like you say, 65% of docs thinking it's worth a shot when someone is dying in front of you doesn't equate to 65% having the knowledge that this is a cure.

 

[SusanHaack]

Take out the tonic, lime, ice and replace the glass with a bottle and you have Saint_mAnn's favourite libation.

 

[doowdniw]

WE already know you can't be truthful or factual neither.

Double negative. Intentional, I'm sure.

 

[dolf]

Either or, neither nor. It looks weird when people mix them.

 

[thør]

Vodka tonic is even better than gin. Squeeze of lime and lots of ice.

Summer is coming. What a great summer drink.

Depends on the gin.

A great drink and no sinus issues from the hops.

 

[sigh]

Depends on the gin.

A great drink and no sinus issues from the hops.

True enough, but I'll take Tito's over Bombay most days.

 

[thør]

True enough, but I'll take Tito's over Bombay most days.

The tonic makes a difference, too.

Tito's is decent.

My bottle of Permafrost vodka might be the last I get, because the company went out of biz. An alcoholic shouldn't be running a distillery.

 

[sigh]

The tonic makes a difference, too.

Tito's is decent.

My bottle of Permafrost vodka might be the last I get, because the company went out of biz. An alcoholic shouldn't be running a distillery.

But as long as there's a Texas, I'll have my Tito's. I think. Who knows who's an alcoholic after all?

My real passion is bourbon. I'm still exploring all that Kentucky has to offer.

 

[thør]

But as long as there's a Texas, I'll have my Tito's. I think. Who knows who's an alcoholic after all?

My real passion is bourbon. I'm still exploring all that Kentucky has to offer.

Toby was a also a poor businessman. They did make great booze.

 

[Biggs_Darklighter]

https://i.imgflip.com/3w6rxw.jpg

I fucked her

 

[Lancecastor19]

And no, despite the wisdom of Lance, maybe doesn't mean yes.

It might.

 

[Conager]

No it isn't. It's hardly used for malaria anywhere anymore because for the most part, the infecting parasite has become resistant to it. The most commonly used cocktail used for prophylaxis and treatment for malaria is a mix of Atovaquone-proguanil and doxycycline, plus mefloquine or tafenoquine. Tafenoquine is used in some areas because of developing resistance to mefloquine.

Hydroxychloroquine is barely mentioned for malaria anymore. Like chloroquine it's just not efficacious. And yes, it is dangerous. It can trigger arrhythmias even in patients without previous heart disease and its elimination half life is more than a month, meaning it takes a looooooooooooong time (at least 5 months) for it to clear the body. So if you do have a bad reaction to it, it ain't going away any time soon.

So what we have, then, is a a drug with an unknown (definitely unproven) potential for shortening recovery time from coronavirus, but with a well-proven, and fully accepted potential for serious harm, even death. Back when hydroxychloroquine was used for malaria, the risk was balanced by the known benefit it held for treating and preventing malaria. Totally different risk/benefit ratio. Apples and oranges comparison.

And no, despite the wisdom of Lance, maybe doesn't mean yes.

I stand corrected.

Also on the contra side, and possibly why Fouci is skeptical is that it was apparently tried i om(H1N1?) And reported Lee foul she was enthusiastic about it's promise at that time but data taken on that experiment seem to show that it was little better than placebo.

The whole zinc thing seems to come up and get debunked every cold and flu season. Call sorts of speculation about what the action might be and how it works and that it doesn't work and those that's where that it does so I'm a little skeptical about zinc because it's one of those feel good things I think. Kind of like vitamin C and chicken soup. Probably doesn't hurt may help.

 

[Conager]

It might.

It certainly is not "no" as RobbedDownSouth insisted, is it?

I mean if a person means no, no is pretty good way to communicate that. Coupla letters, monosyllabic*, easy to say. Just one vowel, one consonant. Easy-peasy.

May beeeee sounds like a lottavwork and leaves a lot of interesting things for the imagination, yes? A "littele" pregnant with possibilities.

*the word is so short it takes five five syllables and this whole sentence to 'splain how short it be.

 

[Lancecastor19]

If Sigh and I sat thigh to thigh with maybe on her lips, I’d be hard pressed to hear it as a no.