Peregrinator
Hooded On A Hill
- Joined
- May 27, 2004
- Posts
- 89,482
http://www.redorbit.com/news/health/1112779542/diabetes-cure-dogs-human-cure-to-follow-020713/
The therapy is based on the transfer of two genes to the muscle of adult animals, using a new generation of safe vectors known as adeno-associated vectors. These vectors, derived from non-pathogenic viruses, are used in gene therapy and have been successful in treating several diseases.
Dogs that are treated with a single administration of gene therapy showed good glucose control at all times, both when fasting and when fed. The dogs treated with adeno-associated vectors improved their body weight, and had not developed secondary complications four years after treatment.
This is the first study to report long-term control of diabetes in large animals, a feat that had never before been achieved. It is also the first study to report that a single administration of genes to diabetic dogs is able to maintain normoglycemia over longer term.
During the trials, dogs had normal levels of glycosylated proteins, and developed no secondary complications of diabetes after more than four years with the disease.
The therapy is based on the transfer of two genes to the muscle of adult animals, using a new generation of safe vectors known as adeno-associated vectors. These vectors, derived from non-pathogenic viruses, are used in gene therapy and have been successful in treating several diseases.
Dogs that are treated with a single administration of gene therapy showed good glucose control at all times, both when fasting and when fed. The dogs treated with adeno-associated vectors improved their body weight, and had not developed secondary complications four years after treatment.
This is the first study to report long-term control of diabetes in large animals, a feat that had never before been achieved. It is also the first study to report that a single administration of genes to diabetic dogs is able to maintain normoglycemia over longer term.
During the trials, dogs had normal levels of glycosylated proteins, and developed no secondary complications of diabetes after more than four years with the disease.
