New NIH Study: Two-Dose Covid Vaccination Gives Limited Immune Response and More SUS

Study on old mice?

What, if anything, does that prove?

Mice studies can be used to prove that almost anything is carcinogenic. Until the studry is replicated in humans, it was a waste of effort.
 
Older individuals are at higher risk of SARS-CoV-2 infection and severe outcome but the underlying mechanisms are incompletely understood. In addition, how age modulates SARS-CoV-2 re-infection and vaccine breakthrough infections remains largely unexplored. Here, we investigated age-associated SARS-CoV-2 pathogenesis, immune responses, and the occurrence of re-infection and vaccine breakthrough infection utilizing a wild type C57BL/6N mouse model. We demonstrated that interferon and adaptive antibody response upon SARS-CoV-2 challenge are significantly impaired in aged mice in comparison to young mice, which results in more effective virus replication and severe disease manifestations in the respiratory tract. Aged mice also showed increased susceptibility to re-infection due to insufficient immune protection acquired during primary infection. Importantly, two-dose COVID-19 mRNA vaccination conferred limited adaptive immune response among the aged mice which rendered them susceptible to SARS-CoV-2 infection. Collectively, our findings call for tailored and optimized treatment and prevention strategies against SARS-CoV-2 among the older individuals.

Hold up... where do you see *more* susceptible?
 
Aged mice also showed increased susceptibility to re-infection due to insufficient immune protection acquired during primary infection:rolleyes:

They are still mice, no matter how old they are. A mice study proves nothing except that it might be worth funding a human study. Until that is done, nothing is proven.
 
They are still mice, no matter how old they are. A mice study proves nothing except that it might be worth funding a human study. Until that is done, nothing is proven.

one would think

at your advanced age

sanity would have overtaken you:rolleyes:
 
Does AlterEgo even understand the purpose and limitations of a mouse study?
 
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