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You have to understand that in any given scene or situation, all forms of restraint have the possibility to be dangerous. Using something improperly is only one way they can be dangerous.
Education is key and basic understanding of a person's body structure would also come into play. If someone has a bony wrist, metal cuffs could cause bruises and even loss of feeling because of how the metal cuts off circulation in different positions. In some cases, a covering of some soft material might lessen that problem, but metal cuffs with fur just don't have enough. Maybe wrapping the wrist with several layers of cloth, like a wash cloth could help, if metal cuffs are all you have on hand (no pun intended), but metal cuffs are not the only potential problem with restraints misused.
Suspension cuffs are made for suspension and nothing more. If you try to use something other than suspension cuffs to suspend someone's body from a ceiling, etc. you risk muscular problems as well as in joints, not to forget the point of contact on the body. Loss of blood circulation, nerve damage and dislocated joints cold all be a problem, even if you use the proper suspension cuffs and use them for too long.
Leather is good, but it can have issues, too. some buckle cuffs might be too loose buckled in one hole and too tight in the next. Both could cause an issue, depending on what's happening in the scene.
Scarves and ropes are usually soft, but when tied too tight, they are no longer soft and can be just as damaging to the body as anything else. As with metal cuffs, wrapping the wrist with layers of cloth can sometimes help, but don't assume it's going to be the fix for everything. It can sometimes only delay a problem that was always there.
Whatever you use for your bondage play, think about length of time and positioning of the body in those bonds, and just use common sense on what might happen when thinking of those two issues. Also, communication with the submissive is key, asking if they have sharp or dull pain issues, loss of feeling or painful joints. Not everybody is the same. Some weigh less than others and everybody has a different skeletal and muscular make up, so there is no norm when thinking of these safety issues. And for the submissive, don't try to be strong and take the pain. Some pain is good, but other pain is a potential problem.
The primary concern is always the welfare of a submissive, well above any erotic pleasure. Plan ahead to make sure everything is going to work, before you find out too late that it isn't.