Moderna vs. Pfizer efficacy against Delta variant

[RobDownSouth]

So we're seeing some actual research now on the efficacy of Moderna and Pfizer Coronavirus vaccines in preventing "breakthrough" Delta variant infections.

The score:

• Pfizer: stops 88% of major Delta variant breakthrough infections
• Moderna: stops 93% of major Delta variant breakthrough infections

"major" is defined here as "requiring hospitalization".
600,000+ cases studied.

Scientists are now trying to determine if this is primarily because the Moderna vaccine requires a 4 week period between first and second injections, and Pfizer only requires a 3 week period. They're trying to determine if the one week extra between doses builds up a stronger antibody base.

 

[ll74]

If you're going to give specific numbers like this, please provide the source for that data.

So we're seeing some actual research now on the efficacy of Moderna and Pfizer Coronavirus vaccines in preventing "breakthrough" Delta variant infections.

The score:

• Pfizer: stops 88% of major Delta variant breakthrough infections
• Moderna: stops 93% of major Delta variant breakthrough infections

"major" is defined here as "requiring hospitalization".
600,000+ cases studied.

Scientists are now trying to determine if this is primarily because the Moderna vaccine requires a 4 week period between first and second injections, and Pfizer only requires a 3 week period. They're trying to determine if the one week extra between doses builds up a stronger antibody base.

 

[RobDownSouth]

If you're going to give specific numbers like this, please provide the source for that data.

https://yourlocalepidemiologist.substack.com/p/moderna-vs-pfizer-is-there-a-difference

 

[ll74]

https://yourlocalepidemiologist.substack.com/p/moderna-vs-pfizer-is-there-a-difference

Thank you.

 

[ll74]

That agrees with my earlier thread regarding immunity increase for those previously infected.

The immune response was even greater for vaccinated people who had been previously infected.

This is an interesting sidenote worth repeating

So the number of antibodies were higher, but as you may know, those numbers aren’t really meaningful. We don’t know what antibody number you need to say “you’re protected”.

The thing I really like about the source you provided, is that they admit the limitations of their observations and the analysis they provide from those observations....this is probably one of the biggest things that transactional people and "hesitant" people need to understand.

Even the best people in the world make decisions based on limited information. The difference is that the experts in agencies around the world have both the adequate perspective and adequate resources to address those gaps of information.

…Or this could be nothing. The aforementioned studies had limitations (like all studies do), which may bias the conclusions. We need more studies showing the same thing among different populations to be more confident. We also need to figure out the “why”.

 

[ShyBiGuy954]

https://64.media.tumblr.com/76a17b81ea40c51cac14a806afedaffa/e011893b6d92758d-2d/s1280x1920/7c6e8dbfb147a07a4766ce7815295ea46192969e.png

 

[coati]

I would like to see data on the incidence of vaccination side effects, comparing Pfizer and Moderna. I had significant side effects from Moderna, that lasted anywhere from 30 to 48 hours, starting about 8 hours following injection.

My primary care doctor said this was probably due to the response of my immunity system, which might not be a bad thing with regard to building longer-term preparation for a possible infection with COVID. Anecdotally, I heard more stories about Moderna side effects than of Pfizer side effects. The V-Safe program must have some hard data on the incidence of side effects of both types of mRNA vaccinations.

I'm willing to put up with vaccination side effects if it means better efficacy for avoiding severe disease.

 

[ll74]

I would like to see data on the incidence of vaccination side effects, comparing Pfizer and Moderna. I had significant side effects from Moderna, that lasted anywhere from 30 to 48 hours, starting about 8 hours following injection.

My primary care doctor said this was probably due to the response of my immunity system, which might not be a bad thing with regard to building longer-term preparation for a possible infection with COVID. Anecdotally, I heard more stories about Moderna side effects than of Pfizer side effects. The V-Safe program must have some hard data on the incidence of side effects of both types of mRNA vaccinations.

I'm willing to put up with vaccination side effects if it means better efficacy for avoiding severe disease.

I had a fever for about 4 hours the second night after the vaccine. Other than that, no side effects. I've known several who have had more of a cold-type reaction..like they're sick.....congestion, fever, chills for longer periods of time, though pass within a week.

 

[jaF0]

I would like to see data on the incidence of vaccination side effects, comparing Pfizer and Moderna. I had significant side effects from Moderna, that lasted anywhere from 30 to 48 hours, starting about 8 hours following injection.

I had none from either M. Zero. Minor achiness in the immediate area of shot 1. Mentioned it Shot Giver at time of number two ... he thought maybe he hit muscle just a bit. Not even that after shot two.




The minor symptoms I've read about are headache, mild fever, general tired feeling. Nothing of any significance.

 

[coati]

I had a fever for about 4 hours the second night after the vaccine. Other than that, no side effects. I've known several who have had more of a cold-type reaction..like they're sick.....congestion, fever, chills for longer periods of time, though pass within a week.

My physician said that aggressiveness of immunity response to COVID vaccination varies greatly among his patients. One of the causes of severe COVID disease is the cascading effect of immunity response in people who have a genetic tendency toward auto-immune disease, where your T-cells go crazy with response and start causing enormous inflammation and collateral damage to normal cells. He thought it was a good thing for people with aggressive immunity systems to "rehearse" distinguishing between cells with spike proteins on the surface and normal cells.

 

[Fuzzy1975]

I had zero symptoms from the first dose of Moderna, except a sore arm, where the nurse injected me. I blame that on her shitty technique.

For the second dose, I didn't even have a sore arm, but the next day I was tired a bit, with a real low grade fever (99.1) for about 6 hrs.

 

[BabyBoomer50s]

Huge blow to all the Pfizer snobs who bragged about getting the better vaccine. That was a short-lived status symbol. Now Moderna subjects getting the last laugh.

 

[Fuzzy1975]

Huge blow to all the Pfizer snobs who bragged about getting the better vaccine. That was a short-lived status symbol. Now Moderna subjects getting the last laugh.

For you, this is a pretty stupid post. It's at the level of a BoBo or Busybody....

 

[jaF0]

For you, this is a pretty stupid post. It's at the level of a BoBo or Busybody....

BoomBoom IS BB.

They're all one and the same person.

 

[BabyBoomer50s]

For you, this is a pretty stupid post. It's at the level of a BoBo or Busybody....

Sorry you took it seriously. It was a satirical poke some cultural silliness last spring. Regardless of what vaccine you took, you can relax.

https://slate.com/human-interest/2021/04/best-vaccine-choice-pfizer-joke.html

https://www.theatlantic.com/technol...izer-gang-and-sadness-vaccine-culture/618755/

 

[Wrong Element]

I think the difference is one of degree. I don't believe anyone is claiming "Whoa, Pfizer sucks now."

As a Pfizer guy who is mow more than 6 months past the first jab, and is not at the 65-and-over level where boosters are more likely to eventually be recommended, I will continue to follow this with interest.

 

[BabyBoomer50s]

I think the difference is one of degree. I don't believe anyone is claiming "Whoa, Pfizer sucks now."

As a Pfizer guy who is mow more than 6 months past the first jab, and is not at the 65-and-over level where boosters are more likely to eventually be recommended, I will continue to follow this with interest.

Agree. The Mayo preprint is a quality piece of work and the limitations discussed in the paper need to be considered. It’s impossible to control every single variable and get a precise number. It’s like choosing between Ginger and Mary Ann. If you’re stuck on a deserted island, you’ll fuck whichever one is available.

 

[colddiesel]

SputnikV and Sinopharm are better products than either Pfizer or Moderna.

 

[Fuzzy1975]

Sorry you took it seriously. It was a satirical poke some cultural silliness last spring. Regardless of what vaccine you took, you can relax.

https://slate.com/human-interest/2021/04/best-vaccine-choice-pfizer-joke.html

https://www.theatlantic.com/technol...izer-gang-and-sadness-vaccine-culture/618755/

Sarcasm is hard to pull off in the written form. Maybe that's why emojis showed up eh?