Pfizer Phizzle

[Lazaran]

Pfizer Pfizzle

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PBS just interviewed the CEO of Pfizer and I must say I was left more than a little disappointed by his presentation and his projections.

IF everything goes PERFECTLY 12.5 million Americans MAY be able to get the two dose vaccination this year. He projects that Pfizer will be able to PRODUCE enough vaccine for 75 million two dose vaccinations for Americans by the end of next year. The Pfizer vaccine is also very temperature sensitive and must be stored at minus 80 degrees Celsius. The vaccine has also not been peer reviewed and its side effects are in question.

The long term outlook is promising, but anyone who thought that this was going to dramatically change things in the near future is deluding themselves.

Keep the champagne and the vaccine on ice I guess.

 

[butters]

it's a work in progress but the experts always said it'd take to the end of next year, maybe into 2022, before enough vaccine could be produced and taken up by enough people to have a serious impact.

fortunately for people awaiting a vaccine, work on an influenza shot was already well underway and, through this, work in developing mRNA which has been crucial in covid vaccine research since the pandemic arrived. Jansen has some good history and sounds like a scinetist to have on your side in dangerous days; the article linked below is extensive and interesting:
https://www.statnews.com/2020/08/24...cientist-with-two-best-sellers-to-her-credit/

The company’s Covid-19 efforts grew out of its work in something far more mundane: trying to create a new type of influenza shot. In August 2018, Pfizer paid BioNTech $120 million —- with the potential to pay another $305 million, plus double-digit royalties — to create a new flu vaccine.

It was a step into working with a bold new technology: mRNA.

This substance, known as messenger RNA, is the genetic messenger that the body uses to turn DNA code into proteins. Get it into a cell, and it should turn it into a protein factory. That could be used to turn cells into drug — -or vaccine — factories. The idea was to use this tech to replace the slow and somewhat haphazard method used to produce flu shots in chicken eggs or, sometimes, in insect or other cells.

Moderna, based in Cambridge, Mass., has made the biggest headlines in the mRNA field, raising a stunning $3.9 billion, according to Pitchbook, from private and public markets. Pfizer’s partner, BioNTech, was founded by a Turkish-born oncologist, researcher, and entrepreneur, Ugur Sahin.

When SARS-CoV-2 began spreading more widely in February — potentially airborne, contagious, but more deadly than influenza — Sahin was immediately worried. It had the markings of a pandemic. He pushed his team to come up with potential vaccines. When he thought his team had something, he called Jansen. Would Pfizer want to work on vaccine with BioNTech? “Of course,” Jansen said. She told him she had been about to call herself.

Pfizer and BioNTech decided to test not one but four potential mRNA vaccines that used different ways of chemically preparing the mRNA and the particle of fats it must be encased in so the body doesn’t destroy it. All four, like all the Covid-19 vaccines in clinical development, are based around the spike protein, which the virus uses to hijack its way into human cells.

The companies released data on one vaccine, based on the part of the spike protein that grabs the cell the virus is entering, on July 1. Data for a second, containing the full spike protein, was released Aug. 20 — and showed it had fewer side effects. That is the one being studied in the giant study design to prove it prevents infection.

Although both the Moderna and Pfizer-BioNTech vaccines use mRNA, the technology has never been used in an approved drug. Other companies, with their own technologies, are in hot pursuit. AstraZeneca, Johnson & Johnson, Novavax, and Sanofi will start their own giant trials in short order this fall. Experts hope that, to fill the global need, they all work.

Jansen is confident. There’s not enough data to tell how the vaccines will compare. All of these vaccine efforts produce antibodies against SARS-CoV-2, but no one knows what antibody levels are needed to protect people from infection.

a more recent october article with relevant links
https://www.foxbusiness.com/healthc...ines-development-wont-be-affected-by-politics

In a letter to employees Thursday, Pfizer CEO Albert Bourla doubled down on his promise that the pharmaceutical company's development of a coronavirus vaccine will "never succumb to political pressure."

"The only pressure we feel — and it weighs heavy — are the billions of people, millions of businesses and hundreds of government officials that are depending on us," Bourla wrote.

The comment came a month after telling CBS' Face the Nation that he turned down taxpayer money to "liberate our scientists from any bureaucracy" and "keep Pfizer out of politics."

"When you get money from someone, that always comes with strings,” the executive said. “They want to see how you're going to progress, what type of moves you're going to do, they want reports. I didn't want to have any of that. Basically, I gave them an open checkbook so that they can worry only about scientific challenges, not anything else. And also, I wanted to keep Pfizer out of politics, by the way."

 

[Dribble]

The problem...as it is with all lipid-coated viruses.. this puppy has now mutated from the original virus ...to 2 new viruses. So now, we are fighting 3...not one. Science sucks

 

[butters]

The problem...as it is with all lipid-coated viruses.. this puppy has now mutated from the original virus ...to 2 new viruses. So now, we are fighting 3...not one. Science sucks

yep, but it's amazing at the same time and what's been learned already won't go to waste.

 

[Dribble]

yep, but it's amazing at the same time and what's been learned already won't go to waste.

this is an amazing virus. Very unique. Don't get me wrong...i support Pfizer's efforts. I am just tempering expectations. There is only one path for us to walk. But how we walk this is the difference between 500k deaths and 1.5 million deaths.

 

[KeithD]

this is an amazing virus. Very unique. Don't get me wrong...i support Pfizer's efforts. I am just tempering expectations. There is only one path for us to walk. But how we walk this is the difference between 500k deaths and 1.5 million deaths.

And, thanks to Trump and friends, we're falling behind in the fight.

 

[Lazaran]

yep, but it's amazing at the same time and what's been learned already won't go to waste.

Advancing the science is always a positive, just as long as things don't get oversold.

When the news came out today the stock market and certain outlets reacted with a fairly exaggerated sense of euphoria.

This was definitely a big play but not an immediate game changer.

It IS better than Hydroxychloroquine though, so.........

 

[Dribble]

Advancing the science is always a positive, just as long as things don't get oversold.

When the news came out today the stock market and certain outlets reacted with a fairly exaggerated sense of euphoria.

This was definitely a big play but not an immediate game changer.

It IS better than Hydroxychloroquine though, so.........

It will take the market some getting used to after 4 years of fabricated ups and downs

 

[Carnal_Flower]

I heard a report today that Pfizer called Biden directly with this news. That must have burned Trump. it's made me think better of them. Obviously they waited until after the election to announce it because they didn't want to help the Idiot.

 

[Dribble]

I heard a report today that Pfizer called Biden directly with this news. That must have burned Trump. it's made me think better of them. Obviously they waited until after the election to announce it because they didn't want to help the Idiot.

They also refused Govt money. They didn't want to be pressured and wanted the science to dictate the efficacy

 

[phrodeau]

The problem...as it is with all lipid-coated viruses.. this puppy has now mutated from the original virus ...to 2 new viruses. So now, we are fighting 3...not one. Science sucks

The mutations are variations of the same virus. If it changed substantially, it would be called Covid 20.

 

[IrezumiKiss]

The mutations are variations of the same virus. If it changed substantially, it would be called Covid 20.

In the upcoming Michael Bay-produced plague movie Songbird, the virus has mutated to Covid-23.

the way we're going with the current administration's clown shoe operating, by the time we actually get the vaccine the movie might be out-of-date.