From Dusk Till Dawn: Starts out as a standard Tarantino crime story -- but then, halfway through, there's vampires?! 
2001: A Space Odyssey: At the beginning and end we have this standard SF plot about extraterrestrials manipulating human evolution. Sandwiched between, we have a completely unrelated standard SF plot about a rogue artificial intelligence. WTF?!
Any others?
2001: A Space Odyssey: At the beginning and end we have this standard SF plot about extraterrestrials manipulating human evolution. Sandwiched between, we have a completely unrelated standard SF plot about a rogue artificial intelligence. WTF?!
Any others?