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A new treatment seems to be very helpful for alzheimers

That is good news! My neuroborelliosis is a neural inflammation, I'll mention it to my neurologist when I see him later this month.
 
I followed the link from the report to the tests on Ankylosing Spondilitis which I have. Unfortunately those tests proved only that more work needs to be done.

Og
 
Pure said:
maybe there's hope.

the abstract for the study is at

http://www.jneuroinflammation.com/content/5/1/2/abstract

the study is at

http://www.jneuroinflammation.com/content/pdf/1742-2094-5-2.pdf
Click to expand...
Thank's J.

Have to wait till the full pdf is published, currently I can only open the abstract and cover page of the pdf.

Unclear as to how it works, my virus has gotten under the outer sheath of the nerve covering, a supposedly impermeable layer, it's why massive doses of anti-biotic are used in a vain hope that somehow some permeate the layer - but they do more damage than good in some patients and are generally no longer prescribed except for early diagnosed patients. What happens with me is the inflammation goes through cycles, flaring, blocking the neural pathway and leading to unanticipated consequence. It take NASID inhibitors, classed as a narcotic, to control inflammation. If the alpha-TFN is also only controlling inflammation, it's unlikely to cure the underlying virus.

ETA: Alzhiemers is caused by plaques (effectively scarring) on the nerves (as far as I understand it) the plaques in turn cause inflammation hence controlling the inflammation can bring rapid change, but as sure as eggs is eggs, alpha-TFN is not going to dissolve the plaques.
 
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Any breakthrough is welcome to Alzheimer's patients. I lived through losing my grandmother to this disease, and watching a loved one deteriorate daily is very painful.

I hope the researchers fix any potential problems with the therapy, and it is approved soon, for those suffering, and their families.
 
steelersfan said:
Any breakthrough is welcome to Alzheimer's patients. I lived through losing my grandmother to this disease, and watching a loved one deteriorate daily is very painful.

I hope the researchers fix any potential problems with the therapy, and it is approved soon, for those suffering, and their families.
Click to expand...

Reading the article, the alpha-TFN is already approved. though not for Alzheimer's. I shouldn't imagine it will take long to obtain approval for Alzheimer's treatment given the condition those patients suffer.
 
neonlyte said:
Reading the article, the alpha-TFN is already approved. though not for Alzheimer's. I shouldn't imagine it will take long to obtain approval for Alzheimer's treatment given the condition those patients suffer.
Click to expand...

I hope so, but you know the FDA can be overwhelmingly obstinate and asinine with approving new medicines and applications.
 
neon, i could email you the pdf file, if you like. PM me your email
j.
 
This is great news! As an only child dealing with children of my own and a widowed mother with early stages of the disease, this has made my day!
 
sweetsubsarahh said:
Off to study.

We lost my husband's mother to Alzheimer's.

It's a tragic thing.
Click to expand...

Just read the pdf. Pure sent me. Remarkable. I did the same test the referenced patient took a few weeks ago. When you look at the before and after test performance, it seems a wonder drug.

steelersfan: the pdf. confirms clinical trials on Alzheimer's suffers have been underway for three years, I hope that means approval is sooner rather than later.
 
off topic: I did a report on AS for pathology just before graduation. Nifty! But... that has to be unpleasant, Og.

Neon - It sounds like what happened to you is the myelin sheath covering the axons of the white matter in your brain/spinal cord either isn't or wasn't being produced correctly, and it left gaps in the protective myelin layer. That allowed the virus to get into the axons of the neurons and cause the inflammation.

As for alzheimer's itself... Alzheimers is plaques built up around neurons and tangles in the structures that make up the axons of the cells themselves. Most of the times the plaques build up around the myelin sheath, which effectively makes it impossible for the cells to absorb enough of the nutrients they need and makes it impossible for them to release the waste products into the interstitial (between cell) fluid to be taken away. They starve and die in their own waste products at the same time.

The tangles are formed in threadlike structures that run inside the axon and carry electronic impulses to the axon tip, which triggers the release of neurotransmitters. Those are the chemicals that jump the synapse and are picked up by the dendrites of the next nerve, so that sensations can travel along the neuron path. Once the tangles are formed, the impulses aren't carried along the axon correctly. Sometimes not at all. This can cause some major problems with movement and reaction to stimuli. Again, these tangles can cause death of the cells themselves.

for a crash course on how neurons work

What may be the worst part about this particular disease is the fact that symptoms don't show up right away. By the time people are showing changes in behaviour or forgetfulness, or whatever (since it can have an effect on any part of the brain, symptoms vary from person to person), there has already been fairly extensive damage to the central nervous system. Enough of the neurons have died that there has already been a fairly significant amount of shrinking of the brain in certain areas. Again, depending on where the disease hit first.

It's good that they're finding ways to slow down the advance of this, and it shows that there is a good amount of hope for the people that have to suffer through dealing with it. Maybe sometime in the near future they'll be able to stop it before it starts.
 
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MaeveoSliabh said:
off topic: I did a report on AS for pathology just before graduation. Nifty! But... that has to be unpleasant, Og.

Neon - It sounds like what happened to you is the myelin sheath covering the axons of the white matter in your brain/spinal cord either isn't or wasn't being produced correctly, and it left gaps in the protective myelin layer. That allowed the virus to get into the axons of the neurons and cause the inflammation.

As for alzheimer's itself... Alzheimers is plaques built up around neurons and tangles in the structures that make up the axons of the cells themselves. Most of the times the plaques build up around the myelin sheath, which effectively makes it impossible for the cells to absorb enough of the nutrients they need and makes it impossible for them to release the waste products into the interstitial (between cell) fluid to be taken away. They starve and die in their own waste products at the same time.

The tangles are formed in threadlike structures that run inside the axon and carry electronic impulses to the axon tip, which triggers the release of neurotransmitters. Those are the chemicals that jump the synapse and are picked up by the dendrites of the next nerve, so that sensations can travel along the neuron path. Once the tangles are formed, the impulses aren't carried along the axon correctly. Sometimes not at all. This can cause some major problems with movement and reaction to stimuli. Again, these tangles can cause death of the cells themselves.

for a crash course on how neurons work

What may be the worst part about this particular disease is the fact that symptoms don't show up right away. By the time people are showing changes in behaviour or forgetfulness, or whatever (since it can have an effect on any part of the brain, symptoms vary from person to person), there has already been fairly extensive damage to the central nervous system. Enough of the neurons have died that there has already been a fairly significant amount of shrinking of the brain in certain areas. Again, depending on where the disease hit first.

It's good that they're finding ways to slow down the advance of this, and it shows that there is a good amount of hope for the people that have to suffer through dealing with it. Maybe sometime in the near future they'll be able to stop it before it starts.
Click to expand...
That is fantastic information and accurately describes what I believe is going on within my body. In my case, it has only effected short term memory but has severe motor-neurone reaction, mostly unpredictable, including momentary blindness, severe and almost permanent leg cramps, trembling hands. I also have a kind of ghostly Palsy facial symptom, like a hair being dragged over the surface about half an inch above where I touch, but only, usually, on one side. I have all the symptoms of early Alzheimer's, but I don't have Alzheimer's. Mine is Lyme neuro-Borelliosis.

I'm writing a story about a guy who controls objects by nerve stimulation - your references help hugely with the technical language. I maight ask you to read it some time to see if the language stacks up ;)
 
neonlyte said:
That is fantastic information and accurately describes what I believe is going on within my body. In my case, it has only effected short term memory but has severe motor-neurone reaction, mostly unpredictable, including momentary blindness, severe and almost permanent leg cramps, trembling hands. I also have a kind of ghostly Palsy facial symptom, like a hair being dragged over the surface about half an inch above where I touch, but only, usually, on one side. I have all the symptoms of early Alzheimer's, but I don't have Alzheimer's. Mine is Lyme neuro-Borelliosis.

I'm writing a story about a guy who controls objects by nerve stimulation - your references help hugely with the technical language. I maight ask you to read it some time to see if the language stacks up ;)
Click to expand...
Short term memory would be in areas of the frontal lobe, behind the forehead, probably closer to the back area of that lobe since most of your problems are with motor neurons. The blindness and facial thing would probably be damage to the occipital area and one of the cranial nerves that go to the face, or could all be caused by cranial nerve inflammation, since they have to pass through tiny holes in the skull structure itself. I don't know, I'm not qualified to diagnose anything, but that's what it SOUNDS like due to what areas of the body are controlled by what areas of the brain.

I'd be more than happy to look over your story for you! Let me know when, and I'll shuffle my work load around to accomodate. :D
 
I hope it works. Anyone who has seen what this disease does will hope the same.
Since I will be at a funeral this afternoon for an Aunt that had it, I understand. :(

Good luck all successes are welcome :D
 
It is so great that they are finding new ways to treat this disease. As a CNA that has worked in a number of nursing homes it is one of the saddest things in the world. It is even worse for the families that watch it happen to a loved one! Horray for researchers!!!
 
Given that this particular drug is already approved for other conditions, I agree that it might well reach the theraputic community earlier than later. It all depends on the political motivation for the FDA, unfortunately. Viagra and its cousins came through really fast because they were previously approved. Given that we have already lost one very popular president to Alzheimer's, my suspician is that this will go through more quickly than a treatment for, say, Parkinson's.
 
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