trysail
Catch Me Who Can
- Joined
- Nov 8, 2005
- Posts
- 25,593
Boehringer Ingelheim
Pradaxa
Bristol-Myers
Pfizer
apixaban
Eliquis
Bayer
Johnson & Johnson
Xarelto
rivaroxaban
Bayer Drops as Rival’s Study Triggers Xarelto Estimate Cuts
By Naomi Kresge and Michelle Fay Cortez
Jun 23, 2011
Pfizer, Bayer Studies Show Clot Drugs Safe as Standard Therapy
By Naomi Kresge and Chris Kay
Aug 31, 2010
Bayer Reports Unexpected Fourth-Quarter Loss on Schering Brand Writedown
By Naomi Kresge
Feb 28, 2011
Pfizer, Bristol-Myers Pill May Lead $9B Stroke Market
By Naomi Kresge and Albertina Torsoli
Aug 29, 2011
Bayer Rises as Blood Thinner Wins U.S. Panel’s Backing for Heart Condition
By Anna Edney and Naomi Kresge
Sep 9, 2011
Warfarin
Coumadin
Boehringer Ingelheim
Pradaxa
Bristol-Myers
Pfizer
apixaban
Eliquis
Bayer
Xarelto
Johnson & Johnson
rivaroxaban
Pradaxa
Bristol-Myers
Pfizer
apixaban
Eliquis
Bayer
Johnson & Johnson
Xarelto
rivaroxaban
Bayer Drops as Rival’s Study Triggers Xarelto Estimate Cuts
By Naomi Kresge and Michelle Fay Cortez
Jun 23, 2011
Bayer AG (BAYN) fell the most in more than two years in Frankfurt trading after a rival to its Xarelto blood thinner outperformed in a study, prompting analysts to slash their sales estimates for the German drugmaker’s product.
Bayer dropped 6.3 percent, or 3.63 euros, the biggest decline since March 2009, and closed at 54.40 euros.
Pfizer Inc. (PFE) and Bristol-Myers Squibb Co. (BMY) yesterday published details of a study that positions their experimental drug apixaban, expected to lag Xarelto, as a potential leader in the $7 billion market for warding off strokes in patients with a condition known as atrial fibrillation. The research shifts the balance of power among the three competitors vying to replace warfarin, a 50-year-old medicine first used as rat poison.
“All is not lost for Xarelto,” Alistair Campbell, an analyst at Berenberg Bank in London, wrote today in a note to clients. “But it seems prudent to revisit our market share assumptions.” Campbell cut his peak annual sales estimate for the drug to $1.9 billion from $4.3 billion. He described Xarelto as “the most important pipeline drug and the main catalyst” for Bayer’s share price this year.
The Leverkusen, Germany-based company’s peak sales forecast of more than 2 billion euros ($2.85 billion) remains unchanged and Bayer is confident that the medicine will be “an effective option,” said spokesman Oliver Renner. Bayer markets the drug with New Brunswick, New Jersey-based Johnson & Johnson. (JNJ)
Merger Question
“Clearly this is not a good day for Bayer, but the debate now is about whether it becomes a very big product or merely a big product,” said Jack Scannell, a London-based analyst for Sanford C. Bernstein & Co. “It’s nothing like the kind of terrible situation where you have thousands of reps selling a product that suddenly turned out to be dangerous.”
It’s too early to say whether competition from apixaban will put pressure on Bayer to use acquisitions to build its pharmaceutical unit, Scannell said. He rates Bayer’s shares “market-perform.”
Bayer Chief Executive Officer Marijn Dekkers said in May the company would be open to a merger of equals to strengthen its health-care unit without paying a premium for a large acquisition. Bayer is relying on its two chemical units to drive growth this year, forecasting that revenue gains at the drug division will lag the market.
Bayer has declined 1.6 percent so far this year, trailing the 2.2 percent rise in the Bloomberg index that tracks 18 European drugmakers.
‘Ideal Drug Profile’
Pfizer and Bristol-Myers said that apixaban prevented more strokes with less major bleeding than traditional treatment in a study of patients with irregular heartbeats. Pfizer and Bristol-Myers plan to file for regulatory approval in the U.S. and Europe by year’s end, the New York-based companies said yesterday in a statement summarizing the data.
“As it stands today, we have to assume apixaban may well have come closest to the ideal drug profile,” Campbell said. He cut his recommendation on Bayer shares to “hold” from “buy.”
Both Xarelto and apixaban will compete for irregular heartbeat patients against Boehringer Ingelheim GmbH’s Pradaxa, approved last year, in the contest to replace warfarin, a sensitive medicine that requires regular laboratory tests to ensure patients get the proper dose.
Xarelto awaits U.S. and European approval in atrial fibrillation, an irregular heartbeat condition that puts patients at a higher risk for strokes. The Food and Drug Administration is expected to rule next month on the blood thinner for orthopedic surgery patients, a smaller market.
Aristotle Study
Apixaban has been shown effective in treating the minority of patients who aren’t candidates for warfarin, according to results published in the March 3 New England Journal of Medicine. It is better than aspirin in preventing strokes in these patients, the study found.
The new study, called Aristotle, compared twice-daily apixaban to warfarin in 18,206 patients with atrial fibrillation, according to a March 2010 description of the trial in American Heart Journal. The drug met its primary goal of showing apixaban wasn’t inferior to warfarin in preventing strokes and clots that cause blood-vessel blockages.
It also was successful in two secondary goals: the drug was more effective than warfarin and led to fewer cases of major bleeding, Pfizer and Bristol-Myers said in yesterday’s statement. Pradaxa, the rival from Boehringer, was more effective than warfarin with similar bleeding at a high dose and as effective as warfarin with less bleeding at a lower dose. Apixaban was more effective and safer, the companies said.
Spokesmen for Pfizer and Bristol-Myers declined to provide additional details about the study results. The findings will be presented at the European Society of Cardiology meeting in Paris in August.
http://www.bloomberg.com/news/2011-...in-frankfurt-on-rival-drug-study-results.html
Pfizer, Bayer Studies Show Clot Drugs Safe as Standard Therapy
By Naomi Kresge and Chris Kay
Aug 31, 2010
Pfizer Inc. and Bayer AG revealed study results today that may give their medicines a foothold in a $10-billion-a-year market to prevent clots that cause strokes and deadly lung damage.
The research provided evidence that Pfizer’s apixaban and Bayer’s Xarelto are as safe as existing therapy, which may ease concerns among doctors who are seeking a replacement for warfarin, a powerful and unwieldy blood thinner used for more than a half-century. Apixaban beat aspirin at preventing strokes in patients with irregular heartbeat, while Xarelto matched standard treatments for clots in the legs and lungs.
At stake is a share in a warfarin-replacement market that could reach $10 billion to $20 billion a year, according to an estimate from Seamus Fernandez, an analyst with Leerink Swann & Co. Doctors and patients will “insist” on using a replacement as soon as one is available for warfarin, which requires regular blood tests and can leave patients vulnerable to deadly clots or uncontrollable bleeding at too low or high a dose, said Ralph Brindis, president of the American College of Cardiology and a cardiologist at Oakland Medical Center in California.
“We’re getting pretty close to the holy grail in finding a replacement for warfarin,” Brindis said in an interview. “I don’t know which one is going to win or lose in that family, but the body of evidence is growing.”
Pfizer rose 5 cents, or 0.3 percent, to $15.91 at 4 p.m. in New York Stock Exchange composite trading, while partner Bristol-Myers Squibb Co. rose 23 cents, or 0.9 percent, to $26.08. Bayer rose 1.15 euros, or 2.4 percent, to 48.18 euros in Frankfurt trading, and partner Johnson & Johnson fell 28 cents, or 0.5 percent, to $57.02 in New York.
Boehringer’s Pradaxa
Boehringer Ingelheim GmbH may be the first drugmaker to win U.S. approval of a revolutionary alternative to warfarin, which is derived from rat poison. U.S. regulatory advisers will review Pradaxa, already approved in Europe to prevent clots following hip and knee surgery, on Sept. 20.
Pradaxa, apixaban and Xarelto interfere with the body’s own clotting mechanisms to minimize strokes, lung clots and extended leg clots, commonly at a risk of increased bleeding, Brindis said. Apixaban, which is still being tested, and Xarelto, which is approved in Europe for hip and knee surgery patients, appear to be effective and safe, perhaps safer than the current standard, he said.
Apixaban Results
Patients who took apixaban were 54 percent less likely to have a stroke or damaging clot than those who took aspirin in a study of 5,600 patients who couldn’t use warfarin, researchers said today at the European Society of Cardiology conference in Stockholm. Apixaban and aspirin showed a similar risk of major bleeding, a feared side effect of blood thinners, according to the study, dubbed Averroes after a 12th century Islamic philosopher.
“The use of aspirin will probably be reduced after this study,” said Harald Arnesen, a professor at Ullevaal University Hospital in Oslo.
Warfarin typically reduces the rate of stroke 40 percent more than aspirin, Larry Biegelsen, a New York-based analyst for Wells Fargo Securities, wrote in a note to investors on Aug. 30. That’s a less potent effect than apixaban showed in today’s trial.
Results from the larger 18,000-patient Aristotle study comparing apixaban with warfarin in patients with an irregular heartbeat called atrial fibrillation are expected in the first half of next year, Tim Anderson, a New York-based analyst with Bernstein Research, said today in a note to clients.
Xarelto Results
“Aspirin isn’t the recommended treatment simply because there’s significant amounts of clinical data that shows that in fact protection is greater on warfarin,” said Nick Turner, a London-based analyst at Mirabaud Securities, in a telephone interview today. “So exactly how well a drug compares to aspirin is probably not that significant.”
Xarelto matched the standard therapy of Sanofi-Aventis SA’s Lovenox plus warfarin at blocking blood clots in the lungs and legs, researchers said today in a study of more than 3,400 patients. Some 2.1 percent of those in the Xarelto group developed clots compared with 3 percent of people taking the older standard treatments.
Patients who took Xarelto were 33 percent less likely to develop either clots or major internal bleeding, Bayer said. The Leverkusen, Germany-based drugmaker is developing Xarelto with Johnson & Johnson. About 8.1 percent of patients in both treatment groups developed serious bleeding, the study found.
The company designed the study, dubbed Einstein-DVT, to see whether the once-a-day pill could match the existing therapies, which are “very, very effective,” said lead researcher Harry Bueller, of Academic Medical Center in Amsterdam.
Bayer’s Plans
Medicines to prevent clots after knee surgery or in the lungs and legs are a small part of the blood thinner market, said Flemming Oernskov, head of the women’s health and general medicine unit at Bayer. The much bigger market is in atrial fibrillation, Oernskov said in an interview.
Bayer has said it plans to present its trial on Xarelto versus warfarin in atrial fibrillation patients at the American Heart Association conference in November.
“We think that when all indications are there, we have all the trials and it has worked out well, it could be for us as a company over 2 billion euros in annual revenue,” the Bayer executive said. “You can imagine this market will be several factors higher than the 2 billion euros.”
http://www.bloomberg.com/news/2010-...show-clot-drugs-safe-as-standard-therapy.html
Bayer Reports Unexpected Fourth-Quarter Loss on Schering Brand Writedown
By Naomi Kresge
Feb 28, 2011
Bayer AG posted its first quarterly loss in seven years on a writedown of the Schering drug brand and said pharmaceutical sales growth isn’t likely to match the market this year.
The net loss totaled 145 million euros ($199.5 million), compared with a 153 million-euro profit a year earlier, the Leverkusen, Germany-based company said today in a statement. The result missed the average estimate of a 160.6 million-euro profit of 7 analysts surveyed by Bloomberg. Bayer said it’s targeting sales growth of 4 percent to 6 percent this year.
Bayer took a 405 million-euro impairment charge on the Schering brand, which it no longer plans to use. Bayer’s forecast shows drug sales growth hinges on a potential new best- seller, the blood-thinner Xarelto, said Karl Heinz Koch, a Zurich-based analyst for Helvea SA.
“It’s dependent on timing and growth rate for Xarelto,” Koch said in a telephone interview today. He rates Bayer’s shares “buy.” “What they’re saying is that 2011 will remain slowish.”
Bayer rose 1.38 euros, or 2.5 percent, to 56.18 euros in Frankfurt trading, the biggest gain in six weeks. The stock returned 14 percent including reinvested dividends in the past year before today, compared with a 34 percent return for the Bloomberg Europe Chemicals Index.
Three Divisions
The drugs and chemicals conglomerate is still happy with its three divisions selling medicines, plastics and crop chemicals, Chief Executive Officer Marijn Dekkers said in a press conference today.
Divesting a unit to raise cash for an acquisition would be an “extreme option,” Dekkers said.
“Looking is a big word,” the executive said in answer to a question about whether Bayer is seeking a deal big enough to require the sale of a unit. “You don’t have to look far, because there are only 20 companies that qualify as a big acquisition. We are at the moment happy with the three subgroups we have.”
Bayer estimates the market for new blood thinners including Xarelto may exceed 10 billion euros annually. The pill’s sales may peak at more than 2 billion euros, Dekkers said.
Bayer has said it expects U.S. regulators to decide this year whether Xarelto may be used in irregular heartbeat patients. Patients with an irregular heartbeat, or atrial fibrillation, make up the biggest market for the new blood thinners, according to Bayer. The company filed for approval to sell the drug for the same patient group in Europe in January.
‘Uncertainty’
“The uncertainty is large,” with investors expecting trial results this year for a rival product by Pfizer Inc. and Bristol-Myers Squibb Co., Jack Scannell, a London-based analyst for Sanford C. Bernstein Ltd., wrote in a note to investors before the results. Scannell rates Bayer’s shares “outperform” mostly because of the promise of the chemicals unit, he wrote.
Xarelto will face competition from a rival approved last year in the U.S., privately held German drugmaker Boehringer Ingelheim GmbH’s blood-thinner Pradaxa.
Revenue Forecast
Revenue rose 14 percent to 9.01 billion euros, exceeding the average estimate of 8.52 billion euros. Sales this year will be between 35 billion euros and 36 billion euros, the company said, less than the 36.1 billion-euro average estimate compiled by Bloomberg.
Sales at Bayer’s drug unit rose 7.3 percent to 4.47 billion euros. Bayer expects sales for the unit to increase by a low to mid-single-digit percentage this year, with earnings before interest, tax, depreciation and amortization showing a “small improvement” before special items.
Government reforms of health systems cut sales and earnings by 160 million euros last year. The cost will likely climb to between 270 million euros and 300 million euros this year, with more than 100 million euros of the impact coming from the U.S., Dekkers said.
Bayer booked the first 62 million euros of the estimated 1 billion-euro cost of a reorganization announced last year to shift resources to product development and emerging markets. The reshuffle will cost 500 million euros this year, Dekkers said.
The company also said last year it would unify its health operations under the name Bayer, eliminating the Schering brand acquired in its 2006 purchase of German rival Schering AG.
Revenue from plastics and other chemicals at the MaterialScience division rose 28 percent to 2.58 billion euros.
Sales of pesticides and other crop chemicals increased 18 percent to 1.65 billion euros.
http://www.bloomberg.com/news/2011-...quarter-loss-on-schering-brand-writedown.html
Pfizer, Bristol-Myers Pill May Lead $9B Stroke Market
By Naomi Kresge and Albertina Torsoli
Aug 29, 2011
Pfizer Inc. (PFE)’s and Bristol-Myers Squibb Co. (BMY)’s Eliquis will lead the market for stroke-preventing blood thinners after “best-in-class” clinical trial results that marry safety with effectiveness, analysts said.
The twice-daily pill had a 31 percent lower risk of major bleeding, a feared side effect of blood thinners, than the current standard treatment, warfarin, researchers said yesterday at the European Society of Cardiology’s conference in Paris. Patients on Eliquis had an 11 percent reduced risk of dying, the first time a warfarin replacement has saved lives in a study.
Pfizer and Bristol-Myers may now take 60 percent of the market for blood thinners to ward off strokes in people with an irregular heartbeat, according to analysts for ISI Group and Leerink Swann & Co. Leerink estimates sales of warfarin replacements will reach $7 billion to $9 billion a year.
“The bleeding profile is phenomenal and trumps everything else,” Mark Schoenebaum, a New York-based analyst for ISI, said in a telephone interview. “Clearly, this drug will be the leader in the market.”
Yesterday’s results may mean an additional $1.1 billion in peak sales for Eliquis, also known as apixaban, Leerink’s Seamus Fernandez said in a report to investors today. The Boston-based analyst now forecasts the drug will garner revenue of $4.2 billion by 2017, writing that it’s “best-in-class” for safety and reducing deaths.
Two Competitors
Pfizer shares traded at the equivalent of $18.45 at 11:30 a.m. Paris time in European trading, 1.3 percent above the Aug. 26 closing price in New York Stock Exchange composite trading. Bristol-Myers rose 1.5 percent to the equivalent of $29.16.
Pfizer and Bristol-Myers trailed two competitors in the race to bring a warfarin replacement to market. Boehringer Ingelheim GmbH’s Pradaxa was the first, approved last year in the U.S. Bayer AG (BAYN) and Johnson & Johnson (JNJ) also have a candidate, Xarelto, due for regulatory review in the U.S. next month.
Until the Paris conference, the two U.S. drugmakers had only compared Eliquis with aspirin. Now cardiologists have results of two large trials showing the drug is safe, a potentially compelling argument, said Lars Wallentin, a cardiologist at Uppsala Clinical Research Center in Sweden who worked on both Eliquis and Pradaxa.
“There is an edge to apixaban, I would admit,” Wallentin said in an interview at the conference.
Fewer Strokes
Irregular heartbeat, or atrial fibrillation, is the biggest part of the market for Eliquis and its competitors. Other smaller groups of patients, such as people who’ve had hip and knee surgery, could generate an additional $3 billion to $6 billion in sales a year, Fernandez said.
Eliquis also prevented 21 percent more strokes than warfarin in the Aristotle study presented yesterday. For every 1,000 patients treated during the trial, it prevented a stroke in six people, major bleeding in 15 people and death in eight people, investigators wrote in a New England Journal of Medicine article published to coincide with the presentation in Paris. Pfizer and Bristol-Myers funded the research, which followed 18,200 patients.
“The answer is crystal clear: patients will do better on this drug,” lead investigator Christopher Granger, of the Duke Clinical Research Institute in Durham, North Carolina, said in an interview at the conference. Lower cost is the only reason for patients to continue taking warfarin, he said.
Blood Tests
Doctors had been eager for a replacement for warfarin because patients need regular blood tests to ensure they’re getting a safe, effective dose of the older drug.
Eliquis was especially impressive because there was evidence it beat warfarin even in patients who were getting the optimal dose, Harvard University cardiologist Elliott Antman said in an interview. Antman is leading studies of another potential competitor, Daiichi Sankyo Co.’s edoxaban.
If a patient is stable on warfarin and doesn’t mind a monthly doctor’s visit for a blood test, there may be no reason to switch to a new, more expensive medicine, Ralph Brindis, senior adviser for cardiovascular disease at Northern California Kaiser Permanente, said in an interview. Warfarin, a generic drug, costs $4 a month, plus about $20 for blood tests, according to a January presentation by the University of Utah Health Care Thrombosis Service.
Atrial fibrillation occurs when the upper chambers of the heart quiver rather than contract, allowing blood to pool and form clots. More than 2.5 million Americans suffer from it, and 11,000 die every year.
Pradaxa, Xarelto
Pradaxa and Xarelto didn’t significantly extend patients’ lives in studies, though both showed a trend toward being able to do so, Jessica Mega, a cardiologist at Brigham and Women’s Hospital in Boston, wrote in an editorial published alongside the results in the journal. Yet all three appear to be better on some measure than warfarin, Mega wrote.
Boehringer’s Pradaxa has the most to lose from good Eliquis results, Larry Biegelsen, a New York-based analyst for Wells Fargo Securities, wrote in a note to clients before the study was published. Bayer’s Xarelto was studied in a more high-risk group of patients than Eliquis or Pradaxa and could maintain a market niche because it’s a once-daily pill, Biegelsen said.
Warfarin is also once-daily. Both Eliquis and Pradaxa must be taken twice each day.
Pfizer and Bristol-Myers plan to submit Eliquis for U.S. and European regulatory approval by year-end.
Bristol-Myers and Pfizer “are two of the best cardiovascular marketers out there,” Leerink’s Fernandez said. “Put this together with the data, and you have a clear winner.”
http://www.bloomberg.com/news/2011-...lood-thinner-eliquis-cut-deaths-in-study.html
Bayer Rises as Blood Thinner Wins U.S. Panel’s Backing for Heart Condition
By Anna Edney and Naomi Kresge
Sep 9, 2011
Bayer AG (BAYN) rose the most in 10 months in Frankfurt trading after its blood thinner Xarelto won an advisory panel’s support as a treatment to prevent stroke in patients with the most common abnormal heart rhythm.
The drug, known chemically as rivaroxaban, was recommended for atrial fibrillation patients in a 9-2 vote with one abstention by advisers to the Food and Drug Administration meeting yesterday in Adelphi, Maryland. The agency is scheduled to decide whether to approve Xarelto by Nov. 5 and isn’t required to follow the recommendation.
The FDA staff recommended Sept. 6 that the medicine not be cleared for the heart patients because study results didn’t show it would be effective or safe enough. Warfarin, the current standard of care, wasn’t adequately used in a Xarelto study, potentially giving the new treatment from Bayer and partner Johnson & Johnson (JNJ) an unfair advantage, the agency’s staff said in its report.
Xarelto is as effective as “warfarin for patients that really need it,” Philip Sager, an advisory panel member, said. “There are obviously a number of other things that will have to be discussed and worked out.”
Sager is a doctor and a member of the Cardiac Safety Research Consortium in San Francisco.
Earlier Approval
Atrial fibrillation affects more than 2 million Americans, according to the American Heart Association. J&J, based in New Brunswick, New Jersey, markets Xarelto in the U.S. and pays royalties on sales to Bayer, based in Leverkusen, Germany. The German drugmaker sells Xarelto outside the U.S. The partners won U.S. approval July 1 to market the drug for prevention of blood clots after knee or hip replacement surgery.
Physicians for the past half-century have used warfarin, a drug that requires constant monitoring and dose adjustments, to prevent stroke in atrial fibrillation patients, according to the New England Journal of Medicine.
The FDA staff also said the Xarelto results showed excess strokes in patients using the blood thinner who then switched to warfarin. The report suggested the companies conduct a transition trial.
Robert Temple, director of the FDA’s office of drug evaluation, said the panel members differed on what patients would benefit most from the new blood thinner. Several advisers, including Sager, voiced concern that Xarelto should be approved only for patients who don’t respond to other treatments.
‘Pyrrhic Victory’
“The recommendation for approval is potentially a Pyrrhic victory,” Mark Purcell, a London-based analyst for Barclays Capital, wrote in a note to clients today. “The FDA may very well opt for a label that restricts Xarelto to a small part of the market.” Purcell rates Bayer’s shares “equal weight.”
Panel members didn’t support J&J’s claim that Xarelto should be labeled superior to warfarin. Martin Rose, a clinical reviewer with the FDA, said J&J indicated to him that it would no longer pursue a superiority claim as the company sought U.S. approval.
Peter DiBattiste, global therapeutic area head of cardiovascular and metabolism at J&J, disputed Rose’s claim.
“Our position has not changed,” DiBattiste said.
Warfarin’s dose must be maintained in a specific range to keep the blood from clotting and also from getting too thin and putting patients at risk of severe bleeding, particularly brain hemorrhage, Jack Scannell, an analyst with Sanford Bernstein Ltd. in London, said in a note Sept. 7.
Recommended Treatment Range
The comparison group of patients given warfarin during the Xarelto study was in the recommended treatment range just 55 percent of the time. In separate studies of Xarelto’s rivals, the comparison groups on warfarin did better.
Patients remained in the therapeutic window 64 percent of the time during a trial of Boehringer Ingelheim GmbH’s Pradaxa, approved by the FDA for the heart patients in October, and 62 percent of the time for Pfizer Inc. (PFE) and Bristol-Myers Squibb Co. (BMY)’s apixaban, known as Eliquis, now being tested in clinical trials.
The New England Journal of Medicine, which published the results, said Xarelto was tested on higher-risk patients.
The panel discussed the use of warfarin in the Xarelto study at length.
“This can get us into some very dangerous territory,” said Steven Nissen, chairman of the department of cardiovascular medicine at the Cleveland Clinic Foundation. Nissen voted against Xarelto approval.
‘Best-in-Class’
Even if the FDA agrees with the staff report and rejects Xarelto, Scannell said 30 percent of drugs that the agency originally turns away are approved.
A delay in approval may erase any advantage Xarelto might have had by beating Eliquis to the market. Eliquis presented “best-in-class” results Aug. 28 at the European Society of Cardiology’s conference in Paris. The pill had a 31 percent lower risk of major bleeding, a safety concern with blood thinners, compared with warfarin and an 11 percent reduced risk of dying, the first time a warfarin replacement has saved lives in a clinical trial.
About 300,000 patients have been prescribed Pradaxa, Glenn Silver, a spokesman for Boehringer, said in an e-mail.
Bayer said sales of the blood thinner Xarelto will reach at least 2 billion euros ($2.8 billion) a year outside the U.S., leaving its peak sales estimate unchanged even if the drug doesn’t get FDA regulatory approval in atrial fibrillation patients.
The drugmaker is “confident” it will reach the sales target in markets outside the U.S., including Europe and Japan, said Astrid Kranz, a spokeswoman for the company.
http://www.bloomberg.com/news/2011-...-s-advisers-approval-for-heart-condition.html
Warfarin
Coumadin
Boehringer Ingelheim
Pradaxa
Bristol-Myers
Pfizer
apixaban
Eliquis
Bayer
Xarelto
Johnson & Johnson
rivaroxaban
Last edited: